Clinical studies

/Clinical studies
Clinical studies2019-06-12T18:59:14+00:00

Clinical studies

Current and future clinical research involving the Personal Medicine Profile (PMP)

The POCT study

Personal medicine at Danish pharmacies. The objective of this study will be to evaluate the PMP test at Danish pharmacies. Endpoints will include pharmacists and patients perception of the test and evaluation of the ethical and societal perspectives of introducing the PMP test as a regular pharmacy practice. Current status: The study protocol and design is under preparation in collaboration with Department of Pharmaceutics, University of Copenhagen.

The ICANPIC study

Personal medicine in Canada. The objective of the study was to evaluate the feasibility of implementing personalized medication services into community pharmacy practice and to assess the number of drug therapy problems identified as a result of pharmacogenomic screening. The study was carried out in two community pharmacies in Toronto, Canada One hundred patients taking a mean of 4.9 chronic medications were enrolled in the study. Pharmacists cited the most common reasons for pharmacogenomic  (PGx) testing as ineffective therapy (43.0%), to address an adverse reaction (32.6%), and to guide initiation of therapy (10.4%).  An average of 1.3 drug therapy problems directly related to the PGx testing were identified per patient. Pharmacist recommendations included change in therapy (60.3%), dose adjustment (13.2%), discontinuation of a drug (4.4%), and increased monitoring (22.1%). Current status: The results of the study have been published in Journal of the American Pharmacists Association 57 (2017) 624-629

The ABILITY 2 study

Personal medicine and pain treatment. The objective of the ABILITY-2 study is to help improve pain diagnostics and - treatment. This is done by developing an implementable clinical computerised decision support system based on individual patient characteristics and to identify biomarkers including gene variations (PMP-test) that can be used to individualize treatment i.e. to reliably predict the analgesic response in the individual patient. Current status: The study will be initiated November 2018 and will be carried out at Aleris-Hamlet Hospital in Ringsted Denmark, in collaboration with Mech-Sense, Aalborg University Hospital and Department of Drug Design and Pharmacology, University of Copenhagen.

The OPTINAM study

Personal medicine for acute treatment. The objective of this study will be to obtain "proof of concept" of the value of the PMP test. The test will be used as an integrated part of a medication review  performed for acutely admitted elderly patients. Endpoints will include evalution of the proportion of therapy problems identified by the PMP test. Current status: The study was initiated October 2018 at the Emergency Department at Hvidovre Hospital in collaboration with the research department at Amager-Hvidovre Hospital.

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