Biomarker for clinical studies

The APOXY study was performed at Aalborg University hospital.

The objective was to investigate oral controlled-release formulation and their influence on the relationship between pharmacokinetics and pharmacodynamics and the importance of pharmacogenomics

The study included 15 healthy volunteers, who were treated with oxycodone. A pharmacogenetic analysis and pharmacokinetic/pharmacodynamic analysis was performed.

So far the results for pharmacokinetic and pharmacodynamic data has been published. Read more by Ladebo et al. 2020. Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers. Basic Clin Pharmacol Toxicol. 2020 Mar;126(3):263-276.

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