Systems and processes such as e.g., the metabolic system, the hemostatic system as well as the biotransformation of drugs are still developing in children.
Much medicine will, therefore, act differently in children compared to adults. Although the genetic variations are stable in children, treatment heterogeneity may differ in childhood.
However, PMP can be used for children as the genes are the same for the rest of their life if you are not exposed to e.g., radioactivity or the like. We simply recommend that the clinical consequences and dose adjustments are further adjusted by a pediatrician or used only when the child becomes an adult.