News
New antidepressants study from Norway
The most favourable genotype for SSRI metabolism includes CYP2D6, CYP2C19 and SLC6A - but the findings show a low prevalence. Genotyping of patients treated with selective serotonin reuptake inhibitors | Tidsskrift for Den norske legeforening (tidsskriftet.no)
What can pharmacogenomic do for you?
A short and fine explanation of what pharmacogenomics can do for you. The video is from Florida and therefore no local commercial. http://https://www.youtube.com/watch?v=b9FyOAEXzBw&t=12s
The use of PGx in Nursing Homes
Four Nursing Homes in Ontario. Measurements Potential drug therapy problems (DTPs) for study cohort were identified during a medication review by a pharmacist using pharmacogenetic (PGx) clinical decision support to identify medication change opportunities. The number of DTPs identified during a standard medication review was compared with the number [...]
Approaches and hurdles of implementing PGx in psychiatric clinic
Despite the many hurdles, PGx testing has great promise to optimize medication selection and dosing in psychiatry practice. While the clinical evidence‐base is growing, a collaborative multi‐stakeholderapproach can overcome hurdles discussed in this review. The development of user‐friendly systems for test ordering, guidelines for use and communication of results, [...]
Time course for benefits and risk with dual antiplatelet therapy
Question What is the time course for benefit and risk with dual antiplatelet therapy for individuals with minor ischemic stroke or transient ischemic attack (TIA) who carry CYP2C19 loss-of-function (LOF) alleles? Findings In this secondary analysis of the Ticagrelor or Clopidogrel With Aspirin in High-risk Patients With Acute Nondisabling Cerebrovascular Events II (CHANCE-2) [...]
PGx-tests improves care and reduces healthcare costs
Study among cardiovascular patients confirms that PGx panel testing yields more savings and clinical impact than single gene testing though both are superior to non-personalized approaches to prescribing. Results: Over 15 months, multi-gene testing was least costly and yielded more QALYs compared to both single gene and no testing; [...]