A life with rheumatism
Karen (56 years old) has had arthritis for four years and takes Methotrexate every week to slow down the progression of the disease. She has heard that Methotrexate can be “toxic” and she is so tired of the nausea and tiredness associated with taking this drug. Some days, Karen also needs painkillers and she has doubts about her body being able to tolerate all this medication on the long term. According to her doctor, the treatment, the frequent controls by a specialist and regular blood tests are expected to be life-long.
Most medications exhibit a wide variability in efficacy. A considerable part of this variability is due to inherited variations in genes. The association between the genetic variations and the response and toxicity of anti-inflammatory drugs (NSAIDs, corticosteroids and anti-rheumatic drugs (DMARDs) e.g., Methotrexate and Azathioprine) has not yet been clearly established.
Do not change or stop taking any medication without consulting your doctor.